Chen Zhong Qiang

1984.8- 1989.7 1999.11-1999.12 Nijmegen Sint Marrtenskliniek AO Fellow 1996.9-1996.10, AO- FELLOW 1991.1-1991.12 Dunfermline and West Fife Registrar: 1. 2015.3- 2. 2013.3.18-2015.3 3. 2013.1-2016 4. 2002.6-2012.5 5. 1999.6- 2002.6 6. 1997.11-1999.6: 1. 1999.6- 2. 1997.6- 3. 1992.12-1997.6 4. 1989.7- 1992.12 5. 1984.8- 1989.7 6. 1983.12-1984.6, 1. 2021-01-2024.12 lncRNA HOXA11-AS 2. 2018.01-2021.12,miR-132-3p/miR-196a-5p/miR-490-3p FOXO1 55 3. 2016.1-2019.12 HIF3A 4. 2013.7-2015.6“ ” 70 5. 2013.1-2016.12 OLF 70 6. 2012,8-2014,8 OLF 150 985III 7. 2012 、 、 、 、 8. 2011.5.10-2012.5.31 3 9. 2011.1.1-2013.12.31 261 10. 2011.1.1-2013.12.31 FGF18 33 11. 2010.8.1-2011.9.30 30 12. 2010.7-2012.12 138.2 13. 2010.3.16-2013.3.16 14. 2008.8.1-2011.7.31 1.5 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. AO 11. AO AO; 12. 13. 14. 15. 16. (2000- ) 17. 18. 19. 20. 21. 22. 23. 24. 、 25. 26.; 27.; 28.; 29.. 30. 、 31. 32. 1. 、; 2.; 3.. 4. 2014,“ ” 5. 2013 “ ”,. 6. 2012 “ ” (2010-2012 ),. 7. 2012,“ ” 7. SCI: 1. Zhang Baoliang,Chen Guanghui,Yang Xiaoxi et al. Percutaneous Kyphoplasty Versus Percutaneous Vertebroplasty for Neurologically Intact Osteoporotic Kümmell's Disease: A Systematic Review and Meta-Analysis.[J].Global Spine J, 2021, undefined: 2192568220984129. 2. Yuan Lei,Chen Zhongqiang,Liu Zhongjun et al. Comparison of Anterior Approach and Posterior Circumspinal Decompression in the Treatment of Giant Thoracic Discs.[J].Global Spine J, 2021, undefined: 2192568221989964. 3. Yuan Lei,Chen Zhongqiang,Li Weishi et al. Radiographic and clinical features of thoracic disk disease associated with myelopathy: a retrospective analysis of 257 cases.[J].Eur Spine J, 2021, undefined: undefined. 4. Yuan Lei,Zeng Yan,Chen Zhongqiang et al. Risk Factors Associated With Failure to Reach Minimal Clinically Important Difference After Correction Surgery in Patients With Degenerative Lumbar Scoliosis.[J].Spine (Phila Pa 1976), 2020, 45: E1669-E1676. 5. Yuan Lei,Zeng Yan,Chen Zhongqiang et al. Degenerative lumbar scoliosis patients with proximal junctional kyphosis have lower muscularity, fatty degeneration at the lumbar area.[J].Eur Spine J, 2020, undefined: undefined. 6. Sun Chuiguo,Chen Guanghui,Fan Tianqi et al. Ultrasonic bone scalpel for thoracic spinal decompression: case series and technical note.[J].J Orthop Surg Res, 2020, 15: 309. 7. Chen Guanghui,Fan Tianqi,Yang Xiaoxi et al. The prevalence and clinical characteristics of thoracic spinal stenosis: a systematic review.[J].Eur Spine J, 2020, 29: 2164-2172. 8. Fan Tianqi,Meng Xiangyu,Sun Chuiguo et al. Genome-wide DNA methylation profile analysis in thoracic ossification of the ligamentum flavum.[J].J Cell Mol Med, 2020, 24: 8753-8762. 9. Li Yan, Zeng Yan, Chen Zhongqiang et al. Progressive pseudorheumatoid dysplasia confirmed by whole-exon sequencing in a Chinese adult before corrective surgery.[J].J Orthop Surg Res, 2019, 14: 16. 10. Zhongqiang Chen1?, Chi Zhang3,4,5Xiaoxi Yang1, Xiaochen Qu2, Xiangyu Meng3, Mengtao Li3, Dongwei Fan1, Tianqi Fan1, Ann Y Huang4, MiR-490-3p inhibits osteogenic differentiation in thoracic ligamentum flavum cells by targeting FOXO1 International Journal of Biological Sciences 1457-1465 2018 11. Xiaoxi Yang1, Zhongqiang Chen1*, Xiangyu Meng2, Chuiguo Sun1, Mengtao Li2, Li Shu2, Angiopoietin-2 promotes osteogenic differentiation of thoracic ligamentum flavum cells via modulating the Notch signaling pathway PLoS One 2018 12. Hou X, Chen Z, Sun C, et al.A systematic review of complications in thoracic spine surgery for ossification of ligamentumflavum.[J]. Spinal Cord, 2017. 13. Zeng Y, Qu X, Chen Z, et al. 12Posterior corrective surgery for moderate to severe focal kyphosis in the thoracolumbar spine: 57 cases with minimum 3 years follow-up[J]. European Spine Journal, 2016, 26(7):1-9.. 14. Zhang C, Chen Z, Meng X, Li M, Zhang L, Huang A.PLoS One.The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-α) in thoracic ossification of the ligamentum flavum. 2017 Jun 2;12(6):e0178986. doi: 10.1371/journal.pone.0178986. eCollection 2017. 15. Wang B, Chen Z, Meng X, Li M, Yang X, Zhang C.iTRAQ quantitative proteomic study in patients with thoracic ossification of the ligamentum flavum. BiochemBiophys Res Commun. 2017 Jun 10;487(4):834-839. doi: 10.1016/j.bbrc.2017.04.136. 16. Qu X, Chen Z, Fan D, Xiang S, Sun C, Zeng Y, Li W, Guo Z, Qi Q, Zhong W, Jiang Y.Two novel BMP-2 variants identified in patients with thoracic ossification of the ligamentum flavum. Eur J Hum Genet. 2017 May;25(5):565-571. doi: 10.1038/ejhg.2017.2. 17. Han F, Weishi L, Zhuoran S, Qingwei M, Zhongqiang C.J OrthopSurg (Hong Kong).Sagittal plane analysis of the spine and pelvis in degenerative lumbar scoliosis. 2017 Jan;25(1):2309499016684746. doi: 10.1177/2309499016684746. 18. Zeng Y, Qu X, Chen Z, Yang X, Guo Z, Qi Q, Li W, Sun C.Posterior corrective surgery for moderate to severe focal kyphosis in the thoracolumbar spine: 57 cases with minimum 3 years follow-up. Eur Spine J. 2017 Jul;26(7):1833-1841. doi: 10.1007/s00586-016-4875-8. 19. Ning S, Chen Z, Fan D, Sun C, Zhang C, Zeng Y, Li W, Hou X, Qu X, Ma Y, Yu H.Genetic differences in osteogenic differentiation potency in the thoracic ossification of the ligamentum flavum under cyclic mechanical stress. Int J Mol Med. 2017 Jan;39(1):135-143. doi: 10.3892/ijmm.2016.2803. 20. Qu X, Chen Z, Fan D, Sun C, Zeng Y, Guo Z, Qi Q, Li W.MiR-199b-5p inhibits osteogenic differentiation in ligamentum flavum cells by targeting JAG1 and modulating the Notch signalling pathway. J Cell Mol Med. 2017 Jun;21(6):1159-1170. doi: 10.1111/jcmm.13047. Hou X, Sun C, Liu X, Liu Z, Qi Q, Guo Z, Li W, Zeng Y, Chen Z. Clinical Features of Thoracic Spinal Stenosis-associated Myelopathy: A Retrospective Analysis of 427 Cases. Clinical spine surgery. 2016; 29: 86-9 21. Chen ZQ, Sun CG. Clinical Guideline for Treatment of Symptomatic Thoracic Spinal Stenosis. Orthopaedic surgery. 2015; 7: 208-12. 22. Feng FB, Sun CG, Chen ZQ. Progress on clinical characteristics and identification of location of thoracic ossification of the ligamentum flavum. Orthopaedic surgery. 2015; 7: 87-96. 23. Feng F, Sun C, Chen Z. A diagnostic study of thoracic myelopathy due to ossification of ligamentum flavum. 2015; 24: 947-54. 24.,,The relationship of symptomatic thoracolumbar disc herniation and Scheuermann’s disease,EUROPEAN SPINE JOURNAL,2014 2014(23)1059-1066 25.,, The Influence of Kyphosis Correction Surgery on Pulmonary Function and, SPINE, 2014 26.,,,Radiological signs of Scheuermann's disease and low back pain:,Spine,2014 39(20): 1666-1675 27.,,A comparison between two types of "Scheuerman-disease-like people":thoracolumbar disc herniation patients and healthy volunteers with radiological signs of Scheuermann's disease,Chinese Medical Journal 2014 127 (22) 3862-3866 28.,, Recombinant human bone morphogenetic protein-2-induced ossification of the, JOURNAL OF NEUROSURGERY-SPINE, 2014nian 21(30):334-341 29.,,The posterior surgical treatment for focal kyphosis,EUROPEAN SPINE JOURNAL,2014 23(23):2291-2298 30.,,Circumspinal decompression and fusion through a posterior midline incision,EUROPEAN SPINE JOURNAL,2014 23(2) 373-381 2.473 31. Ning Liu,Zhongqiang Chen,Qiang Qi,Zefeng Shi,The relationship of symptomatic thoracolumbar disc herniation and Scheuermann's disease.European Spine Journal 2013 November 17. 32. Liu N, Chen Z, Qi Q, Li W, Guo Z. Circumspinal decompression and fusion through a posterior midline incision to treat central calcified thoracolumbar disc herniation: a minimal 2-year follow-up study with reconstruction CT. Eur Spine J. 2013 Oct 5. [Epub ahead of print] 33. Lang N, Yuan HS, Wang HL, Liao J, Li M, Guo FX, Shi S, Chen ZQ. Epidemiological survey of ossification of the ligamentum flavum in thoracic spine: CT imaging observation of 993 cases. Eur Spine J. 2013 Apr;22(4):857-62. doi: 10.1007/s00586-012-2492-8. Epub 2012 Sep 15. 34. Yan zeng, Zhongqiang Chen, Chuiguo Sun, et al. Posterior surgical correction of posttraumatic Kyphosis of thoracalumbar segment. Journal of Spinal Disord Tech, 2013, 26: 37-41 35. Yan Zeng, Zhongqiang Chen, Qiang qi, et al. The posterior surgical correction of congenital kyphosis and kyphoscoliosis: 23 cases with minimun 2 years follow-up. Eur Spinal journal, 2013, 22:372-378 36. Li W, Sun Z, Guo Z, Qi Q, Kim SD, Zeng Y, Sun C, Chen Z. Analysis of spinopelvic sagittal alignment in patients with thoracic and thoracolumbar angular kyphosis. Spine (Phila Pa 1976). 2013 Jun 1;38(13):E813-8. 37. Yin X, Chen Z, Liu Z, Song C. Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. Braz J Med Biol Res. 2012 Aug;45(8):693-700. Epub 2012 Apr 26 38. Zeng Y, Chen Z, Guo Z, Qi Q, Li W, Sun C Complications of Correction for Focal Kyphosis After Posterior Osteotomy and the Corresponding Management. "J Spinal Disord Tech."[jour]2012 Feb 10. [Epub ahead of print] 39. Zeng Y, Chen Z, Qi Q, Guo Z, Li W, Sun C, White AP Clinical and radiographic evaluation of posterior surgical correction for the treatment of moderate to severe post-tuberculosis kyphosis in 36 cases with a minimum 2-year follow-up. "J Neurosurg Spine."[jour]2012 Apr;16(4):351-8. Epub 2012 Jan 20. 40. Sun X, Sun C, Liu X, Liu Z, Qi Q, Guo Z, Leng H, Chen Z. The frequency and treatment of dural tears and cerebrospinal fluid leakage in 266 patients with thoracic myelopathy caused by ossification of the ligamentum flavum. ""Spine (Phila Pa 1976)." [jour]2012 May 20;37(12):E702-7. 41. Zeng Y, Chen Z, Sun C, Li W, Qi Q, Guo Z, Zhao Y, Yang Y. Posterior Surgical Correction of Posttraumatic Kyphosis of the Thoracolumbar Segment. "J Spinal Disord Tech."[jour]2011 Sep 29. [Epub ahead of print] 42. Qiqiang,Chen Zhongqiang, Liu ning,Guo Zhaoqing,Shi Zefeng, Liu Zhongjun,Liu Xiaoguang,Li Weishi, Zeng Yan,andSun Chuiguo,Cirumspinal decompression through a single posterior incision to treat thoracolumbar sisc herniation,Chin Med J 2011:124(23):3852-3857 43. Chen Z, Zeng Y, Li W, Guo Z, Qi Q, Sun C. Apical segmental resection osteotomy with dual axial rotation corrective technique for severe focal kyphosis of the thoracolumbar spine. J Neurosurg Spine. 2011 Jan;14(1):106-13. 44. Kong Q, Ma X, Li F, Guo Z, Qi Q, Li W, Yuan H, Wang Z, Chen Z, COL6A1 polymorphisms associated with ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2007 Dec 1;32(25):2834-8. 45. Fan D, Chen Z, Chen Y, Shang Y. Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells.J Biol Chem. 2007; 282(41):29958-66.(IF 5.817) 46. Fan D, Chen Z, Wang D, Guo Z, Qiang Q, Shang Y. Osterix is a key target for mechanical signals in human thoracic ligament flavum cells.J Cell Physiol. 2007;211(3):577-84. (IF 4.222) 47. Y in X, Chen Z, a Guo Z, Dang G,a Ma Q, Wang S. Immortalization of human osteoblasts by transferring human telomerase reverse transcriptase gene. Biochemical and Biophysical Research Communications 2004;315,643-51.(IF 2.891) 48. Song C, Guo Z, Ma Q, Chen Z, Liu Z, Jia H, Dang G. Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells.Biochem Biophys Res Commun. 2003;308(3):458-62. (IF 2.891) 1.,,. [J].,2019,29(11):1023-1027. DOI:10.3969/j.issn.1004-406X.2019.11.10. 2.,,. [J].,2019,39(10):637-644. DOI:10.3760/cma.j.issn.0253-2352.2019.10.007.,,. Andersson [J].,2017,(10):798-800. DOI:10.3760/cma.j.issn.0529-5815.2017.10.020 3.;;;;... 2017-07-25 4.;;;;... 2017-05-25 5.;;;.. 2017-01-25 6.,,. 、 [J].,2016,26(1):11-17.DOI:10.3969/j.issn.1004-406X.2016.01.03. 7.,,,,, 2012,50(1) 8.,,,,, 2011,49(2) 9.;;;;;, -,,2011(6) 10. 、; Kirkham B Wood; -,,2011(3) 11.,,, 2010,48(22) 12.,,,,, 2010,48(16) 13.,,,,, 2009,19(8) 14.,,, 2009,89(31) 15.,,,,, 2008,28(9) 16.,,, 、,, 2008,46(2) 17.;;;;,,,2007(10) 18.,,. [J].,2006,(25). 19.,,. [J].,2006,(12). 20.,,,,. - [J].,2006,(8). 21.,,,,. [J].,2005,(4). 22.,,,. [J].,2004,(11). 23.,. [J].,2003,(17). 24.,,,,,,. [J].,2003,(3). 25.,,,,. [J].,2002,(1). 26.,. [J].,2001,(1). 27.,,,,. [J].,2000,(11). 28.,,,,. [J].,1999,(22). 1.,. [J]., 2020, 40(10):680-688. 2.,,,. [J]., 2020, 40(14):962-970. 3.,. [J]., 2020, v.30;No.278(05):86-91. 4.,,,. [J]., 2020, 40(21):1493-1502. 5.,,,. [J]., 2020, v.18(03):65-69. 6.;;;;... 2017-06-05 7.,,,. [J].,2017,(20):1300-1309. DOI:10.3760/cma.j.issn.0253-2352.2017.20.008. 8.,,. [J].,2018,(1):52-56. 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[J].,2003,(1). 44.,. [J].,2003,(9). 45.,,,,. [J].,2002,(6). 46.,,. [J].,2002,(5). 47.,,,,. [J].,2002,(1). 48.,. Cage [J].,2002,(5). 49.,,. [J].,2001,(2). 50.,,. CT [J].,2001,(5). 51.,. [J].,2001,(2). 52.,,,,,,. [J].,2000,(2). 53.,. [J].,2000,(4). 54.,,. [J].,2000,(2). 55.,,. [J].,2000,(2). 56.,,. CT [J].,2000,(6). 57.,,,. [J].,1999,(5). 58.,,. [J].,1999,(4). 59.,,,. 68 [J].,1999,(11). 60.,,,. [J].,1999,(6). 1. 2017《 》 2. 2013.11 《 》, 3. 2012,《 》 4. 2010,2,《AO - 》., 、 5. 2004.10,,《 》: 6. 2000:138-196,《 》.: 、 、.《AO ASIF 》,, 7. 1995,33(5):285, 、:.: 《 》., 8. 1995∶2014-4413, 、:. ∶.《 》..,