Zhang Chun Lei

2000-2002 MD 1998-1999 1990-1995 2024- 2019- 2015-2018 2012- / 2012-2022 2003-2012 MD 1995-1999 、 1. (PI) 1) (2020) 《LncRNA-RN7SL1 T 》 2) (2020) 《 》 3) (2019) 《LncRNA-HOTAIRM1 T 》 4) (2018) 《 》 5) “ ” (2017) 《 》 6) (2014) 《 T 》 7) (2013) 《 》 8) (2012) 《 》 9) Ladies Leukemia League (2007) 《Selective anti-tumor activity of HDAC inhibitors in cutaneous T-cell lymphoma: from bench to bedside & back》 10) Dermatology Foundation (2006)《Translational study of histone deacetylase inhibitor SAHA in CTCL》 2. (PI) 1) (2019)《 50% ( 50%) (AA) PF-06651600 IIB/III 、 、 、 、 》 2) (2019)《 、 、 、 SHR0302 II 》 3) (2019)《 Upadacitinib III 、 、 、 》 4) (2019)《 DUPILUMAB 、 、 》 5) & (2018 ) 《 、 》 6) (2018)《 LY2439821, 、 、 》 7) (2017)《 Xolair 、 、 、 III 》 8) (2016)《 》 9) (2014)《 5% (HZAP) 、 、 》 10) (2013)《 (600 mg, 8 ) III 、 、 、 、 》 3. SCI ( / ) 1)Wang YM, Li WW, Zhang Q, Gu XG, He XL, Men YH, Zhang CL. Targeting phosphorylation of p21-activated kinase 1 at Thr423 induces cell cycle arrest and apoptosis in cutaneous T-cell lymphoma cells. Acta Derm Venereol 99 (11): 1022-8, 2019. 2)Jiang WW, Wang YM, Wang XY, Zhang Q, Zhu SM, Zhang CL. Role and mechanism of matrine alone and combined with acitretin for HaCaT cells and psoriasis-like murine models. Chin Med J 132 (17): 2079-88, 2019. 3)Wang YM, Gu XG, Li WW, Zhang Q, Zhang CL. PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21. J Dermatol Sci 90 (1): 60-7, 2018. 4)Zhang CL, Li BQ, Zhang X, Hazarika P, Aggarwal BB, Duvic M. Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients’ PBMCs: potential role for STAT-3 and NF-kB signaling. J Invest Dermal 130 (8): 2110-9, 2010. 5)Zhang CL, Li BQ, Gaikwad A, Haridas V, Xu ZX, Gutterman J, Duvic M. Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. J Invest Dermatol 128 (11): 2728-35, 2008. 6)Zhang CL, Toulev A, Kamarashev J, Qin JZ, Dummer R, D?bbeling U. The consequences of p16 tumor suppressor gene inactivation in mycosis fungoides and Sézary syndrome and the role of the bmi-1 and ras oncogenes in disease progression. Hum Pathol 38 (7): 995-1002, 2007. 7)Zhang CL, Richon V, Ni X, Talpur R, Duvic M. Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. J Invest Dermatol 125 (5): 1045-52, 2005. 8)Zhang CL, Ni X, Konopleva M, Andreeff M, Duvic M. The novel synthetic oleanane triterpenoid CDDO induces apoptosis in mycosis fungoides/Sézary syndrome cells. J Invest Dermatol 123 (2): 380-7, 2004. 9)Zhang CL, Kamarashev J, Qin JZ, Dummer R, Burg G, D?bbeling U. Expression of apoptosis regulators in cutaneous T-cell lymphoma cells. J Pathol 200 (2): 249-54, 2003. 10)Zhang CL, Hazarika P, Ni X, Weidner DA, Duvic M. Induction of apoptosis by bexarotene in CTCL cells: relevance to mechanism of therapeutic action. Clin Cancer Res 8 (5): 1234-40, 2002. 1. (ISCL) 2. (ASP) 3. 4. 5. 6. 7. 8. 9. 《 》 10. 《 》 1. (2023 ) 2. (2018 ) 3. (2014 & 2017 ) 4. (2012 ) 5. (2009 ) 6. MD CME (2008 ) 7. CME (2006 ) 8. Albert M. Kligman (2003 ) 9. (1996 ) 10. / (1995 ) 1. 、.《 - 》,, 2023, 2..《 》,, 2020, 3. 、. 《 》,, 2020, 4. 、. “ ” / 《 》,, 2019, 5. 、 、 、.《 》,, 2017, 6..《 》,, 2014, 7. 、. “ ” / 《 》( 10 ),,2024, 8. 、 、. “ ” / “5+3” 《 》( 2 ),,2024, 9. 、. “ ” / 《 》,,2021, 10. 、. 《 》,,2021, 1. (10.29)、 (7.8)、 (5.25) 2. “ ” 3. 4. 《, 》 5. (CCTV-10) 6. (CCTV-4) 7. 8. TV 9. “ - ” 10. 《 》