Wei Rui

20 ( 2030, 5, 2, 3 ), 、. 60, Mol Cancer 、 Diabetes ( 2024, 2023 )、 Diabetologia 、 Metabolism ( 2024,2020 )、 E B ioMedicne SCI 37, Top 5% 8, 2. 、 、,: 2019, 2018, 2023, 2021, 2024, Cardiovascular Diabetolog y 2021, Chronic Diseases and Translational Medicine 2023, 2021, 2016 2014 60, SCI 37.: [1] Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenoca rcinoma. Mol Cancer. 2024, 23(1): 90. ( IF=27.7 ) [2] Fam3a-mediated prohormone convertase switch in α-cells regulates pancreatic GLP-1 production in an Nr4a2-Foxa2-d ependent manner. Metabolism. 2024. Oct 1:156042. ( IF=10.8 ) [3] Gut microbiota - tryptophan metabolism - GLP-1 axis participates in beta-cell regeneration induced by dapagliflozin. Dia betes. 2024, 73(6):926-940. [4] Glucagon a cting at the GLP-1 receptor contributes to β-cell regeneration induced by glucagon receptor antagonism in di abetic mice. Diabetes. 2023, 72:599-610. (, highlight ) [5] Pancreatic alpha cell glucagon–liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes. D iabetologia. 2023, 66(3):535-550 [6] Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 dia betic mice. Metabolism. 2020, 111:154324. ( IF=10.8, ) [7] Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose outp ut. EBioMedicine. 2019, 41:73-84. ( IF= 11. 1, ) [8] Lineage reprogramming: a promising road for pancreatic β cell regeneration. Trends Endocrinol Metab. 2016, 27 (3): 163-176. ( IF= 10. 9 ) [9] SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating ma crophage polarization. Acta Pharmacologica Sinica. 2024. doi: 10.1038/s41401-024-01389-3. [10] Glucagon receptor blockage inhibits β-cell dedifferentiation through FoxO1. Am J Physiol Endocrinol Metab. 20 2 3, 3 24(1):E97-E113 (, APS select award )