Zhang Yao Hua

[email protected],,, PI, 、. &,,. MD Anderson. 2022, 2022.,.,,. Science 、 Nature Cell Biology 、 Circulation 、 Science Translational Medicine, 200.: 2013-2016,, 2009-2012,, 2007-2009,, 2005-2009,,: 2023/10, 2022/01-2023/10, 2017/12 -2021/12, 2017/05-2017/12, 2012/08 -2013/06,: o o o Yaohua Zhang, PhD Principle Investigator, Professor State Key Laboratory of Vascular Homeostasis and Remodeling Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital Peking University Health Science Center [email protected] Dr. Yaohua Zhang, a professor at Peking University Third Hospital, holds the position of Principal Investigator (PI) for the National Key Laboratory of Vascular Homeostasis and Remodeling. Before this, he conducted postdoctoral research at the University of Texas Health Science Center in Houston and the renowned MD Anderson Cancer Center in the United States. Acknowledged for his exceptional contributions, Dr. Zhang was honored with the 2022 Beijing Overseas High-level Talents Youth Program and received funding from the Science Fund Program for Excellent Young Scientists (Overseas) in the same year. His research endeavors primarily delve into the mechanisms behind post-translational protein modifications in cardiovascular diseases, leveraging multi-omics technology. His ultimate aim is to establish biomarkers for disease scoring and stratification, thereby enhancing the accuracy of diagnosis and precision in intervention strategies. In the past five years, he has led or contributed significantly to numerous highly influential academic publications in esteemed international journals such as Science, Nature Cell Biology, Circulation, and Science Translational Medicine, collectively achieving a cumulative impact factor surpassing 200. Education PhD, Biochemistry and Molecular Biology, Peking Union Medical College, 2013-2016 MS, Biochemistry and Molecular Biology, Shanxi University, 2009-2012 Bachelor of Management, Information Management and Information Systems, Shanxi Agricultural University, 2007-2009 Bachelor of Science, Biological Sciences, Shanxi Agricultural University, 2005-2009 Research Experiences 2023/10 to Current Associate professor, Peking University Third Hospital 2022/01-2023/10 Professor, Beijing Institute of Brain Diseases 2017/12 -2021/12 Postdoctoral research fellow, MD Anderson Cancer Center 2017/05 -2017/12 Postdoctoral research fellow, The University of Texas Health Science Center at Houston 2012/08-2013/06 Research Assistant, National Center for Cardiovascular Diseases Research interests o Research on the pathogenesis and diagnosis of heart failure based on protein post-translational modification o Development of biomarkers and molecular imaging probes for stratification of coronary heart disease diagnosis o Research on new protein post-translational modifications and development of new intervention methods for cardiovascular disease Drugs, gut microbiome, and cardiometabolic disease (CMD) Publications · Yaohua Zhang *, Zilong Zhao*, Lisa A Huang*, Yuan Liu, Jun Yao, Chengcao Sun, Yajuan Li, Zhao Zhang, Youqiong Ye, Fei Yuan, Tina K Nguyen, Nikhil Reddy Garlapati, Andrew Wu, Sergey D Egranov, Abigail S Caudle, Aysegul A Sahin, Bora Lim, Laura Beretta, George A Calin, Dihua Yu, Mien-Chie Hung, Michael A Curran, Katayoun Rezvani, Boyi Gan, Zhi Tan, Leng Han#, Chunru Lin#, Liuqing Yang#. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 Jun 12: S1550-4131(23)00186-9. (IF=29.01) · Xu Han, Zihan Yan, Kaiyu Fan, Xueyi Guan, Bohan Hu, Xiang Li, Yunwei Ou, Bing Cui, Lingxuan An, Yaohua Zhang #, Jian Gong#. The combined signatures of telomere and immune cell landscape provide a prognostic and therapeutic biomarker in glioma. Front Immunol. 2023 Aug 17:14:1220100. (IF=7.3) · Yuru Zong, Xuliang Wang, Bing Cui, Xiaowei Xiong, Andrew Wu, Chunru Lin, Yaohua Zhang. Decoding the Regulatory Roles of Non-coding RNAs in Cellular Metabolism and Disease. Molecular Therapy. 2023 Apr 26; S1525-0016(23)00210-1. (IF=12.910) · Yaohua Zhang *#, Chengcao Sun*, Yajuan Li*, Juan Qin*, Kaushik Amancherla, Ying Jing, Qingsong Hu, Ke Liang, Zhao Zhang, Youqiong Ye, Lisa A. Huang, Tina K. Nguyen, Sergey D. Egranov, Joe-Elie Salem, Douglas B. Johnson, Michael A. Curran, Dihua Yu, Leng Han, Radbod Darabi, Liuqing Yang#, Javid J. Moslehi#, Chunru Lin#. Hormonal Therapies Upregulate MANF and Overcome FemaleSusceptibility to Immune Checkpoint-Inhibitor (ICI)-Myocarditis. Sci Transl Med. 2022 Nov 2;14(669): eabo1981. IF=19.319. · Congxia Bai*, Ming Su*, Yaohua Zhang *, Yahui Lin*, Yingying Sun, Li Song, Ning Xiao, Haochen Xu, Hongyan Wen, Meng Zhang, Jiedan Ping, Jing Liu, Rutai Hui, Hao Li#, Jingzhou Chen#. Oviductal Glycoprotein 1Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction with MYH9. Circulation. 2022 Sep 29: 101-161. IF=39.918. · Yaohua Zhang, Yajuan Li, Qingsong Hu et al. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 22,1332-1345 (2020). IF=28.213. · Yajuan Li*, Zhi Tan*, Yaohua Zhang* et al. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021;373(6555):662-673. IF=63.714. · Yajuan Li*, Yaohua Zhang*, Qingsong Hu et al. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med. 2021 Aug 28;13(1):137. IF=15.266. · Qingsong Hu, Youqiong Ye, Li-Chuan Chan, Yaohua Zhang et al. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 20, 835-851 (2019). IF=31.25. · Ming-Ze Yao, Yao-Hua Zhang, Wen-Liang Lu, Miao-Qing Hu, Wei Wang, Ai-Hua Liang*. Phytases: Crystal Structures, Protein Engineering and Potential Biotechnological Applications. Journal of Applied Microbiology. 2012,112(1):1-14. · Mingze Yao, Wenliang Lu, Yaohua Zhang, Ai-hua Liang*, Isolation and identification of two phytase-producing strains from soybean rhizosphere soil and cloning of neutral phytase gene. Food Science. 2012, 07(16).