Combined valvular disease

Combined valvular disease is an acquired heart disease. When two or more heart valves are involved together, it is called combined valvular disease. The vast majority of its causes are rheumatic heart disease. It is usually dominated by mitral valve disease combined with other valvular involvement. Among these, the coexistence of mitral and aortic valve disease is the most common. The valvular lesions may be either stenosis or insufficiency. Different types of lesions all alter the normal blood circulation of the heart, resulting in isolated left ventricular volume overload, isolated pressure overload, or both. This leads to left ventricular hypertrophy and decreased compliance. Clinical manifestations include exertional palpitations, shortness of breath, angina, and murmurs audible on cardiac auscultation.