Intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is characterized by pruritus and jaundice occurring during pregnancy, with high rates of preterm birth and perinatal mortality. Its pathogenesis is closely related to estrogen, and it has now attracted widespread clinical attention. Although many scholars have devoted themselves to research on the pathogenesis of intrahepatic cholestasis of pregnancy over the past 20 years, its exact pathogenesis remains not fully understood. Although intrahepatic cholestasis of pregnancy poses no serious harm to the mother, it has adverse effects on the perinatal infant. In recent years, many experts have been dedicated to research on the early diagnosis and management of intrahepatic cholestasis of pregnancy. The clinical manifestations of intrahepatic cholestasis of pregnancy include pruritus appearing in the middle and late stages of pregnancy, or pruritus coexisting with jaundice, which disappears rapidly after delivery. The main effects of intrahepatic cholestasis of pregnancy on pregnancy prognosis include: preterm birth, fetal distress, postpartum hemorrhage, and obstetric complications.