Carbamate insecticide poisoning

Carbamate insecticides (including carbofuran, carbaryl, isoprocarb, and aldicarb) and common herbicides (including swep, molinate, and barban), with carbofuran being the most commonly used, also known as carbofuran or furadan. Carbofuran has the advantages of strong selectivity, rapid action, and low toxicity to humans and animals. Its basic chemical structure is [formula]. According to different R1, R2, and X substituents, it can generally be divided into 5 categories. The rat oral LD50 is shown in Table 10-2-7. Table 10-2-7 Acute oral LD50 of carbamate insecticides in rats Category LD50 (mg/kg) Naphthyl carbamates (carbaryl) 250-560 Phenyl carbamates (isoprocarb) 260-800 Heterocyclic dimethyl carbamates (isolan) 11-50 Heterocyclic methyl carbamates (carbofuran) 8-14 Oximes (aldicarb) 1-30 Carbamate insecticides have the advantages of strong selectivity, rapid action, and low toxicity to humans and animals. Occupational poisoning mainly occurs during production, product packaging, and use, but is extremely rare; poisoning from intentional ingestion or accidental ingestion is more severe.