Gardner syndrome

Gardner syndrome, also known as Weiner-Gardner syndrome, familial multiple polyposis coli-osteoma-soft tissue tumor syndrome, or familial polyposis coli, is an autosomal dominant hereditary disease and represents multiple manifestations of a single gene. In 1905, Gardner reported that patients with colonic polyposis had a higher chance of developing familial osteomas, soft tissue tumors, and colon cancer; later, in 1958, Smith proposed the triad of colonic polyps, soft tissue tumors, and osteomas as Gardner syndrome. The colonic polyps in this syndrome are all adenomatous polyps, with a canceration rate of 50%, and the osteomas are all benign. Both males and females can be affected, with a family history.