Drug-induced liver disease

Drug-induced liver disease (DILD), abbreviated as drug-induced liver injury, refers to liver damage caused by drugs and/or their metabolites. It can occur in healthy individuals with no previous history of liver disease or in patients with pre-existing serious diseases, who develop varying degrees of liver damage after using certain drugs; all such cases are termed drug-induced liver disease. At present, at least 600 drugs can cause drug-induced liver disease, and its manifestations are the same as those of various human liver diseases, including hepatocellular necrosis, cholestasis, intracellular microvesicular steatosis, chronic hepatitis, or cirrhosis.