Fungal allergic asthma

Clinically, the understanding of fungal allergic asthma has a history of over 200 years. In 1728, John Floyer reported that someone suddenly experienced an asthma attack while visiting a brewery. In 1924, Von Leeuwen proposed that the cause of asthma in patients in the Netherlands was due to dampness. In the same year, in the United States, Cadhan reported 3 cases of asthma induced by wheat rust fungi, and these findings were the prototype of research on fungal allergic asthma. In 1928, German physician Dr. Hansen first formally confirmed that 15% of asthma patients showed positive skin test reactions to Alternaria and Penicillium antigens collected from their living environment, and confirmed that inhaling Alternaria or Penicillium spores in some of these patients could induce asthma attacks. In 1932, Tubs reported a child with asthma who developed attacks after each consumption of fermented food, suggesting that yeast and Candida were triggers for asthma in certain patients. In 1934, Prince et al. used the method of exposing plates to culture fungi in patients' living environments for observation and found that when fungal growth was vigorous, patients' asthma symptoms worsened.