Porphyric peripheral neuropathy

Porphyria, also known as hematoporphyria, is a disorder of pigment metabolism. During heme biosynthesis, genetic defects in certain enzymes related to porphyrin metabolism lead to reduced enzyme activity, causing accumulation of porphyrins and porphyrin precursors in the body, resulting in this disease. Based on different enzyme defects, porphyria is clinically classified into several types, some of which can cause nervous system damage, mainly characterized by peripheral nerve involvement.